Μετάφραση και ανάλυση λέξεων από την τεχνητή νοημοσύνη ChatGPT
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Τι (ποιος) είναι juxtacortical osteosarcoma - ορισμός
![Mixed neural cultures derived from rat embryos were grown under normal conditions (left) or treated with 55mM Potassium for 5 hours (right). Cultures were then stained with antibody to the [[intermediate filament]] protein [[vimentin]] (green), antibody to cFos (red) and with a DNA binding dye (blue). The vimentin antibody reveals non-neuronal cells and the DNA dye shows the nuclei of all cells. The potassium treatment depolarizes the neurons and induces strong expression of cFos in neuronal cell bodies as shown in the right image. Cell culture, Image and antibody generation all performed in the [[EnCor Biotechnology]] laboratory.](https://commons.wikimedia.org/wiki/Special:FilePath/CFos-expression-in-stimulated-neurons.jpg?width=200 "Mixed neural cultures derived from rat embryos were grown under normal conditions (left) or treated with 55mM Potassium for 5 hours (right). Cultures were then stained with antibody to the [[intermediate filament]] protein [[vimentin]] (green), antibody to cFos (red) and with a DNA binding dye (blue). The vimentin antibody reveals non-neuronal cells and the DNA dye shows the nuclei of all cells. The potassium treatment depolarizes the neurons and induces strong expression of cFos in neuronal cell bodies as shown in the right image. Cell culture, Image and antibody generation all performed in the [[EnCor Biotechnology]] laboratory.")
![[[X-ray]] of osteosarcoma of the distal femur in a dog](https://commons.wikimedia.org/wiki/Special:FilePath/Canine osteosarcoma.JPG?width=200 "[[X-ray]] of osteosarcoma of the distal femur in a dog")
![Histopathology of osteosarcoma, showing tumor cells with high [[nuclear pleomorphism]], but relatively less so in cells entrapped in neoplastic bone matrix (appearing pink on this [[H&E stain]]ed slide).](https://commons.wikimedia.org/wiki/Special:FilePath/Histopathology of osteosarcoma, high mag.jpg?width=200 "Histopathology of osteosarcoma, showing tumor cells with high [[nuclear pleomorphism]], but relatively less so in cells entrapped in neoplastic bone matrix (appearing pink on this [[H&E stain]]ed slide).")
![High-magnification micrograph showing osteoid formation in an osteosarcoma [[H&E stain]]](https://commons.wikimedia.org/wiki/Special:FilePath/Osteosarcoma - very high mag.jpg?width=200 "High-magnification micrograph showing osteoid formation in an osteosarcoma [[H&E stain]]")
Βικιπαίδεια
Protein c-Fos is a proto-oncogene that is the human homolog of the retroviral oncogene v-fos. It is encoded in humans by the FOS gene. It was first discovered in rat fibroblasts as the transforming gene of the FBJ MSV (Finkel–Biskis–Jinkins murine osteogenic sarcoma virus) (Curran and Tech, 1982). It is a part of a bigger Fos family of transcription factors which includes c-Fos, FosB, Fra-1 and Fra-2. It has been mapped to chromosome region 14q21→q31. c-Fos encodes a 62 kDa protein, which forms heterodimer with c-jun (part of Jun family of transcription factors), resulting in the formation of AP-1 (Activator Protein-1) complex which binds DNA at AP-1 specific sites at the promoter and enhancer regions of target genes and converts extracellular signals into changes of gene expression. It plays an important role in many cellular functions and has been found to be overexpressed in a variety of cancers.
